Has had a little of puppies and since then her and our Mastiff have become aggressive towards each other to the point it's not fixable. We have kids from 17 to a newborn and can't risk someone getting bite or her getting hurt or killed. She lives indoors and is leash, house, and hand signal trained. No problems with her other than her becoming aggressive with the other female. She loves to cuddle and sleep on the bed with us.